Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy

Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy.

Oxidative stress-induced mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage in peripheral neurons is considered to be important in the development of diabetic neuropathy. Mitochondrial transcription factor A (TFAM) wraps mtDNA and promotes mtDNA replication and transcription. We studied whether overexpression of TFAM reverses experimental peripheral diabetic neuropathy using TFAM tr...

Mitochondrial Degeneration in Experimental Diabetic

Neuropathy 3 Krish Chandrasekaran, Muragundla Anjaneyulu , Tatsuya 4 Inoue Joungil Choi, Avinash Rao Sagi, Chen Chen, Tamomi 5 Ide and James W. Russell. 6 1 Department of Neurology, University of Maryland, Baltimore, Maryland, USA, 2 VA 7 Maryland Health Care System; Principal Investigator, Preclinical Division, Syngene 8 International Ltd., Bangalore, India; Associate Senior Researcher, group ...

metabolic syndrome and mitochondrial transcription factor a

Overexpression of Mitochondrial Genes (Mitochondrial Transcription Factor A and Cytochrome c Oxidase Subunit 1) in Mouse Metaphase II Oocytes following Vitrification via Cryotop

Background: Gamete cryopreservation is an inseparable part of assisted reproductive technology, and vitrification is an effective approach to the cryopreservation of oocytes. The aim of this study was to investigate vitrification effects on the expression levels of mitochondrial transcription factor A (Tfam) and mitochondrial-encoded cytochrome c oxidase subunit 1 (Cox1) in mouse metaphase II o...

p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer

In colorectal cancer, no study has been carried out discovering the relationship among p53, mitochondrial transcription factor A (TFAM) expression and change of mitochondrial DNA (mtDNA) copy number. In our study, co-expression of p53 and TFAM was observed in colon adenocarcinoma tissues, paracancerous tissues and 9 colorectal cancer cell lines. Then, a significant linear correlation was establ...